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We studied the neurologic abnormalities in 41 men with isolated hypogonadotropic hypogonadism.Findings included anosmia,hyposmia,mirror movements,ocular motor abnormalities,cerebellar dysfunction,and pes cavus foot deformity.One-third of the subjects had a family history of delayed sexual maturation.Patients with a family history of delayed sexual maturation had a significantly higher incidence of olfactory dysfunction, mirror movements,and pes cavus foot deformity.Our data suggest that isolated hypogonadotropic hypogonadism and its accompanying neurologic abnormalities may arise from a genetically linked developmental abnormality of CNS structures. |
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